Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
Identifieur interne : 000F94 ( Main/Exploration ); précédent : 000F93; suivant : 000F95Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
Auteurs : Oi-Wing Ng [Singapour] ; Adeline Chia [Singapour] ; Anthony T. Tan [Singapour] ; Ramesh S. Jadi [Singapour] ; Hoe Nam Leong [Singapour] ; Antonio Bertoletti [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- Antigènes d'histocompatibilité de classe I (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient, Déterminants antigéniques des lymphocytes T (immunologie), Humains, Immunité cellulaire, Lymphocytes T CD8+ (immunologie), Mémoire immunologique, Protéines de la matrice virale (immunologie), Protéines nucléocapside (immunologie), Réactions croisées, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Virus du SRAS.
- MESH :
- immunologie : Antigènes d'histocompatibilité de classe I, Déterminants antigéniques des lymphocytes T, Lymphocytes T CD8+, Protéines de la matrice virale, Protéines nucléocapside, Syndrome respiratoire aigu sévère.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Immunité cellulaire, Mémoire immunologique, Réactions croisées, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- CD8-Positive T-Lymphocytes (immunology), Cross Reactions, Epitopes, T-Lymphocyte (immunology), Histocompatibility Antigens Class I (immunology), Humans, Immunity, Cellular, Immunologic Memory, Middle East Respiratory Syndrome Coronavirus, Nucleocapsid Proteins (immunology), SARS Virus, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Viral Matrix Proteins (immunology).
- MESH :
- chemical , immunology : Epitopes, T-Lymphocyte, Histocompatibility Antigens Class I, Nucleocapsid Proteins, Viral Matrix Proteins.
- immunology : CD8-Positive T-Lymphocytes, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- Cross Reactions, Humans, Immunity, Cellular, Immunologic Memory, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
Abstract
Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.
DOI: 10.1016/j.vaccine.2016.02.063
PubMed: 26954467
Affiliations:
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Tan</name><affiliation wicri:level="1"><nlm:affiliation>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Jadi, Ramesh S" sort="Jadi, Ramesh S" uniqKey="Jadi R" first="Ramesh S" last="Jadi">Ramesh S. Jadi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><affiliation wicri:level="1"><nlm:affiliation>Singapore General Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Bertoletti, Antonio" sort="Bertoletti, Antonio" uniqKey="Bertoletti A" first="Antonio" last="Bertoletti">Antonio Bertoletti</name><affiliation wicri:level="1"><nlm:affiliation>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR)</wicri:regionArea><wicri:noRegion>Agency of Science Technology and Research (A*STAR)</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore. Electronic address: Yee_Joo_TAN@NUHS.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</wicri:regionArea><wicri:noRegion>Technology and Research)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Cross Reactions</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunologic Memory</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Nucleocapsid Proteins (immunology)</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Viral Matrix Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mémoire immunologique</term><term>Protéines de la matrice virale (immunologie)</term><term>Protéines nucléocapside (immunologie)</term><term>Réactions croisées</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Histocompatibility Antigens Class I</term><term>Nucleocapsid Proteins</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term><term>Déterminants antigéniques des lymphocytes T</term><term>Lymphocytes T CD8+</term><term>Protéines de la matrice virale</term><term>Protéines nucléocapside</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross Reactions</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunologic Memory</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Immunité cellulaire</term><term>Mémoire immunologique</term><term>Réactions croisées</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.</div></front></TEI><affiliations><list><country><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name></noRegion><name sortKey="Bertoletti, Antonio" sort="Bertoletti, Antonio" uniqKey="Bertoletti A" first="Antonio" last="Bertoletti">Antonio Bertoletti</name><name sortKey="Chia, Adeline" sort="Chia, Adeline" uniqKey="Chia A" first="Adeline" last="Chia">Adeline Chia</name><name sortKey="Jadi, Ramesh S" sort="Jadi, Ramesh S" uniqKey="Jadi R" first="Ramesh S" last="Jadi">Ramesh S. Jadi</name><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><name sortKey="Tan, Anthony T" sort="Tan, Anthony T" uniqKey="Tan A" first="Anthony T" last="Tan">Anthony T. Tan</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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